Dr. Miranda’s Plateau Busting Protocol™

My Plateau Busting protocol is a work in progress, as we discover new information in the literature – we tweak this as needed.  By popular demand, I have enclosed the original protocol  here so people can refer to it, but please know that this protocol works for many people but I am currently putting the final touches on my weight loss book which will have many more options for people.

 

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One of my most popular videos on Youtube is “What To Do When Your Hit a Weight Loss Plateau”, and due to it, and the popularity of my Facebook group  www.facebook.com/WeightLossResources one of the most common things reported to me is that people are hitting plateaus and are at a loss as how to proceed since they have tried everything but they just can’t seem to break through that scale barrier. So, in my quest to help my team members and friends, I got out my pharmacology texts and my physiology texts and took a long, hard look at things to try to figure out how we could best use  certain products to blast through those stubborn weight plateaus and barriers.
After studying these texts and the physiology behind how certain organ systems and pathways work – I had a brainstorm on how to dramatically increase weight loss using a few small dietary changes and chronopharmacology; the study of how biological rhythms interact with metabolism and medication & nutrient absorption. So to put my theory to test, I asked for a spectrum of volunteers from my online groups. I laid out the rules for the trial, and all participants had to have been stuck at a weight loss plateau (or actually gaining weight) for a minimum of a month. It ended up that nearly every participant had been at a plateau for 3-6 months or longer. So we were dealing with some bodies that were very resistant to weight loss. Let me be clear, this was a trial to test a theory. It was not a double-blind clinical study which is virtually impossible to run in the real world because you cannot control or modulate people’s individual diets and lifestyles to the extent that would give you enough controls to have a true clinical objectionable study. My trial centered on three products: a glucose regulating product,  a proteolytic enzyme formula, and a potent probiotic.  The participants were instructed to continue taking any medications that had been prescribed to them and to continue taking any supplements they had been taking with the exception of any ‘weight loss’ products. I issued 5 STEPS that they were to follow:

  • 1) STEP 1 – Ketogenic or “Death to Diabetes®” breakfast comprising of a cup of coffee or tea (if desired) and one of 2 approved breakfasts
  • 2) STEP 2 – Taking 2 capsules of TruFix (from TruVision Health) per day.  An optional step is to drink a glass of Tru Heart & Hydration at this time.
  • 3) STEP 3 – Taking Biotics Research Intenzyme Forte ™ twice daily on an empty stomach
  • 4) STEP 4 – Taking 1-2 capsules of an approved probiotic  at bedtime, on an empty stomach
  • 5) STEP 5 – Twice daily, or more –  drinking a cup+ of tea from the approved list of teas.

Other than that, they were to eat regular meals and to be mindful about excessive carbohydrate intake. They were to continue life as usual. They were instructed NOT to start an exercise program if they hadn’t already been doing it.. We tried to minimize the affect ancillary factors would have on the protocol.

“It’s been barely been over 2 weeks and I’m down 10 lbs with my… products and with just a few changes to what I was already doing!”   Trial Participant

So now you know the basic steps, but you need to understand the science and rationale behind the recommendations:

STEP 1

Upon waking you are allowed to eat the following:
1) 1 cup of coffee or tea ( if you drink coffee or tea) * “Bulletproof Coffee” is acceptable (1 tbsp of organic grass-fed butter blended into your coffee with or without added coconut oil)
2) Only protein for breakfast – eggs, fish, steak, bacon, sausage, left-over meat from the previous night’s dinner. 2-4 oz of protein is fine. The only other acceptable breakfast is the “Death to Diabetes©”1 breakfast – consisting of 3-4 oz of meat or fish along with up to 2 cups of steamed green vegetables dressed with 1 tbsp of olive oil, 2 tbsp of vinegar, and any type of Mrs. Dash™ seasoning. The latter breakfast is better for people who prefer to eat larger meals early in the day.
3) Healthy fats – 1 tbsp of coconut oil, grass-pastured butter, avocado, or raw nuts (raw walnuts, pecans and macadamia nuts are particularly beneficial) may be added to control hunger or cravings.

Rationale: The breakfast needs to be essentially carb-free. Do not ask me if you can have fruit, or yogurt, or cereal, or pancakes, or donuts, or oatmeal, or cheese, or anything else. We want ONLY protein so we are starting off the day by leveling glucose and insulin. Those other foods, even if they are ‘healthy’ choices, will spike your glucose and insulin, and then your TruFix has to work twice as hard to be effective. This is, in effect, a ketogenic or paleo-style breakfast. This type of meal “shifts the body’s metabolic engine from burning carbohydrates to burning fats”2 and improves insulin sensitivity and leptin resistance3. Consuming carbohydrates, even in healthy forms such as those from fruit (fructose) or dairy (lactose) causes surges in blood glucose levels which in turn initiate the release of insulin. People with excess weight have been shown to be insulin resistant4 and therefore if we by pass this, we set the stage for less severe glucose and insulin fluctuations throughout the day. In fact, in his book Death to Diabetes™, researcher DeWayne McCauley postulates that eating a paleo or ketogenic breakfast is the most important factor in modulating glucose levels throughout the day.5

STEP 2


1) Take 2 capsules of TruFix each morning.  

Rationale: There are several. First, we want to regulate glucose and insulin spikes.  Even as little of five extra pounds of body weight indicates some degree of insulin resistance.  One, we are consumingthe TruFix  at  or near the same time the same time as protein. Protein takes longer to digest than carbohydrates and the stomach retains protein containing meals for longer periods of time before it is sent through to the small intestine. This enhances absorption of the TruFix ingredients. Two, for those doing the optional step of drinking the TruHeart & Hydration drink mix,  there is a well established neural-lingual connection between your taste buds and the brain. Primary gustatory fibers synapse centrally in the medulla, so upon consuming sweet substances, the sweet taste receptors in the mouth stimulates the release of dopamine in the brain. We can use this signaling to turn down the body’s desire for carbohydrate-rich or sweet substances; “…sweet taste is modified by circulating hormones. Recently, the effect of leptin on sweet-responding taste cells has generated much interest. Leptin, a protein hormone secreted mainly by adipocytes regulates body mass and suppresses insulin secretion by the activation of ATP-sensitive KCn . Its inhibitory effect on TRCs also involves the activation of a K+ conductance and membrane hyper polarization. Thereby the hormone partially blunts nerve signals indicating sweet taste, which, presumably, makes food less attractive.”6 So, in effect by concentrating the sweetness of Heart & Hydration, and holding it for a slightly prolonged period in the mouth to extend its contact time with taste buds, we are fooling the brain into believing that it has consumed a significant amount of carbohydrates, and it turns down your appetite and cravings for them.

The first few days of trying this new method seemed *very sweet* to me, but as I persevered, I noticed a marked reduction in both my appetite and cravings, as did the trial participants. In order for this neural-lingual activation to work you must be tasting the Heart & Hydration. Do not drink it with a straw, do not use ice (which has a numbing effect on the taste buds), do not cut it with cranberry juice, Mio™ Drops, or any other agent that will alter the taste.

 

STEP 3 –

1) Mid-morning and mid-afternoon take Intenzyme Forte™ . The trial was performed using 1 capsule of  Intenzyme Forte  mid-morning, and 1 capsule mid-afternoon on an empty stomach. Empty stomach usually means 30 minutes+ prior to eating or a minimum of 90 minutes after eating. *This HAS to be taken on an empty stomach or IT WILL NOT WORK! Please note, if you have significant levels of inflammation, you can take 2 capsules twice a day, but for simplicity and to curtail costs, the trial was performed using 1 capsule twice daily.

Rationale: Where do we start? There are so many! First, let’s take a look at how inflammation makes you fat : Inflammation begins within the fat cells themselves. Most people think of inflammation and assume that means joint pain, but inflammation is so much more. At its very core a fat cell is an inflamed cell. “As glucose is moved into fat cells, they produce an excess of Reactive Oxygen Species (ROS) which in turn initiates an inflammatory cascade within the cell”7. As the percentage of body fat increases, the rate of inflammation increases exponentially. This inflammation causes insulin resistance, and can be noted with C-Reactive Protein testing. The inflammatory cascade eventually makes its way to the brain, specifically the hypothalamus, where it causes leptin resistance.8 Leptin is your ‘hunger’ hormone and is noted for controlling your appetite and regulating your metabolism. The more fat you have the greater potential you have for leptin resistance, which affects your glucose regulation, and slows your metabolism which results in more weight gain and insulin resistance. It is a vicious cycle that keeps getting progressively worse. Inflammation within the gut itself, where 80% of immune function resides, further causes both leptin and insulin resistance. An imbalance in the gram-negative bacteria in the gut has been shown to produce an endotoxin called lipopolysaccharide (LPS) and a cytokine cascade which causes inflammation, insulin resistance, and weight gain.9 But I digress, we will get into how bacteria are related to obesity in the next step. Obesity makes fat cells act like they are infected.10 The stimulation of fat cells by excess calories causes the cells to make Major Histocompatibility Complex II (MHCII), which in turn sends your immune system into over-drive, mimicking autoimmune dysfunction.11 This breakthrough in understanding the fat cell may prove to be crucial future weight loss and aging studies.

Intenzyme Forte™ is a proteolytic enzyme formula. When taken on an empty stomach, it can be absorbed intact into the bloodstream12 where it can be directed towards breaking down those inflammatory products in the body. Proteolytic enzymes have been demonstrated to reduce Tumor Necrosis Factor alpha (TNF-a), a cytokine protein that signals inflammatory responses along with other pro-inflammatory mediators such as Prostaglandin E2 and Thromboxanes.13 Autoimmune dysfunction is associated with increased levels of TNF-a.14

In addition to the overwhelming capacity of proteolytic enzymes to interrupt this fat-inflammation cycle, certain ones, including bromelain, have a secondary action of helping the body to utilize insulin more efficiently which in turn helps to keep blood glucose fluctuations less dramatic. 15

To summarize all of this technical jargon : fat cells are inflamed cells. Think of each fat cell like a little water balloon filled with fat. The fat creates chemicals which not only irritate the body, but stimulate the body to keep making more and more fat cells. This is very stressful on the body which finds the inflammatory chemicals hugely irritating, so the body tries to dilute those irritants by sending more water to the area (bloating and swelling) to flush those chemicals away. This not only sends the body down the pathway to blood sugar dysregulation and even diabetes, but can result in premature aging and even autoimmune-type degeneration. Once you have made a fat cell, you can never get rid of them (barring surgery like liposuction) but you can deflate those ‘balloons’ of fat, and turn off the inflammation production. That is what we are trying to achieve with this step.

” I started Plexus on May 24, 2013. I did exceptionally well with weight loss and then November hit. I got stuck. As the weeks passed I saw my numbers going back UP. I tried everything… Nothing was working NOTHING – and no one seemed to have any answers for me except the usual drink your water, what are you eating, did you do the spit test….I just did my 3 week weighs and measurement since I started Dr Miranda’s way of taking my… products…. apparently my inches are on super movement (and keep in mind my weight loss would probably have been more BUT I had a huge “bad” Easter dinner and we hit and all you can eat wing night in this time period!)

So I am back to not having to starve to death and the scales are moving in the right directions!!! In just 2 weeks, I have lost 7.5 inches and 5.3 lbs.

WAHOOOOOOOO! ”  Trial participant

 

STEP 4 –

1 ) At bed time, take 1-2 capsules of a broad spectrum probiotic. Again you want to take your probiotics on an empty stomach so it gets passed through your stomach acid quickly and so it can colonize in your large intestine while you have your longest period of bowel rest. If you take magnesium, this is an ideal time to take it too.

Rationale: An increasing body of evidence suggests that obesity is directly linked to the bacteria in your gut. In fact the bacteria in thin people differs from the bacteria in overweight people. 16 Thin people and overweight people have entirely different strains and ratios of intestinal flora.17 Researchers at Laval University in Canada, found that female test subjects receiving probiotics lost twice as many pounds as those in the placebo group over the course of a twelve week period.18 Furthermore, probiotics may normalize intestinal pH, making it more difficult for candida albicans to thrive, and may crowd out pathogenic bacteria sepcies.19 There are variations of professional opinion on the best way to consume probiotics, but heat and acid are enemies of bacteria, so if you can get the probiotics through the stomach acid as quickly as possible, then you have created optimal conditions for the greatest number of probiotics to survive. Hence the need to take them on an empty stomach. Taking them at night coincides with the greatest period of bowel rest for most individuals, which allows for longer periods of contact between the probiotics and the intestinal mucosa, which may improve the rate of colonization. When you take probiotics with food, they stay in the acidic stomach for much longer, which kills off a greater percentage of the bacteria.

STEP 5 –

1) At some point throughout the day, please consume 2 cups of tea – either hot or cold (make it yourself, do not use premade or commercial preparations) Green tea, Black tea, Dandelion Tea, Yarrow, Rosehip, Cornsilk tea, Roobios, or Pu-Ehr are all acceptable forms. Warm water with the juice of 1 lemon is acceptable as well. Sweeten with stevia or a small amount of table sugar (so its glucose/fructose ratio is balanced) to taste if needed. Mix up these forms of tea. If you use only one type, your body will accommodate, and we will lose the reason why we are adding this to the program. You don’t have to use all of them, but experiment and try at least 2 or 3. You can drink 2 cups at once or drink 1 cup at two different times.

Rationale: All of these teas have a known mild diuretic effect and by keeping them in rotation our body will not accommodate to it- thereby it maintains its effectiveness. Geranax had potent diuretic properties, and this contributed to the immediate weight loss many people experienced when they took it initially. As we already discussed, the body likes to flood inflamed tissues with excess water, so if we drink tea, its mild, natural diuretic properties help us flush those inflammatory by-products from the body, and that will support healthy weight loss. Please note: many of the teas listed, particularly the herbal teas are naturally caffeine-free. Should you choose to use green tea or black tea however, it is the caffeine portion of it which acts like a diuretic, so make sure to purchase regular versions and not decaffeinated ones.

 

Now for the rest of the questions you might have:

  • Meals – Make healthy choices when you can. If you can eat lower amounts of carbohydrates, you should see results faster. Try to eat GOD made foods and avoid as many Man-made foods as possible. *Perfect meals are meat & veggies*
  • If you drink alcohol, limit yourself to one (1) oz of hard liquor or 1 6(oz) glass of wine per day. If you drink more than this, it increases the difficulty you will have losing weight tremendously.
  • Avoid artificial sweeteners
  • Keep your fruits and yogurts as side dishes to your meals – like dessert.
  • If you already exercise, keep continuing what you are doing. Please don’t start a new program at the same time you initiate a new diet. You want to know what is working for you and what isn’t.
  • If you are consuming the beverages as described, please make sure that you are drinking your water. These cups of tea do count towards your daily quota.
  • Please do not skip meals.

We are going to do a few things differently than what you have been doing. Please follow these instructions:

** Start by taking your measurements and writing them down.   When you weigh yourself, do it first thing in the morning after you have gone to the bathroom. Do not wait until after you have eaten, and do not weight yourself later in the day. If you are measuring your blood sugar, please record your average fasting glucose and post-prandial reading (if you track that one. Take photos of yourself if you would like. You always want to weight yourself and take our measurements at the same approximate time of the day**

  1. STEP 1 – Ketogenic or “Death to Diabetes®” breakfast comprising of a cup of coffee or tea (if desired) and one of 2 approved protein based breakfasts
  2.  STEP 2 – TruFix™ , 2 capsules per morning.  Optional — 1 packet of Tru Heart & Hydration mixed into 8-12oz of water and hold it in the mouth for a few seconds before swallowing
  3.  STEP 3 – Take Intenzyme Forte™ twice daily on an empty stomach (mid-morning & mid-afternoon)
  4. STEP 4 – Take 1-2 capsules of an approved probiotic at bedtime, on an empty stomach
  5. STEP 5 – Twice daily, drinking a cup+ of tea from the approved list of teas. (Green tea, Black tea, Dandelion Tea, Yarrow, Rosehip, Cornsilk tea, Roobios, or Pu-Ehr, or water with the juice of 1/2 to 1 whole lemon in it)

Helpful pointers: :

  • Meals – Make healthy choices when you can. If you can eat lower amounts of carbohydrates, you should see results faster. Try to eat GOD made foods and avoid as many Man-made foods as possible. *Perfect meals are meat & veggies*
  • If you drink alcohol, limit yourself to one (1) oz of hard liquor or 1 6(oz) glass of wine per day. If you drink more than this, it increases the difficulty you will have losing weight tremendously.
  • Avoid artificial sweeteners
  • Keep your fruits and yogurts as side dishes to your meals – like dessert.
  • If you already exercise, keep continuing what you are doing. Please don’t start a new program at the same time you start a new diet. You want to know what is working and what is not.
  • If you are consuming the beverages as described, please make sure that you are drinking your water. These cups of tea do count towards your daily quota.
  • Please do not skip meals.

visit https://www.facebook.com/groups/Weightlossresources for help and support.

1. McCulley, DeWayne. Death to Diabetes. North Charleston: BookSurge LLC.© 2005
2. Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers. Retrieved April 26, 2014 from: http://articles.mercola.com/sites/articles/archive/2014/02/02/ketogenic-diet-health-benefits.aspx
3. ibid
4. Hyman, Mark. The Blood Sugar Solution. NY: Little, Brown and Company. ©2012
5. McCulley, DeWayne. Death to Diabetes.
6. Sweet taste signaling. Retrieved April 26, 2014: http://www.qiagen.com/products/genes%20and%20pathways/pathway%20details.aspx?pwid=425
7. How inflammation makes you fat and diabetic (and vice versa).
http://chriskresser.com/how-inflammation-makes-you-fat-and-diabetic-and-vice-
8. ibid
9. ibid
10. Obesity makes fat cells act like they are infected. Retrieved April 26, 2014: http://www.sciencedaily.com/releases/2013/03/130305145145.
11. ibid
12. Proteolytic enzymes among top 10 ways to help decrease inflammation. Retrieved April 26, 2014: http://www.enzymesinc.com/index.php?id=
13. Quell the fire of Inflammation the immense power of proteolytic enzyme therapy. Retrieved April 26, 2014: http://metabolichealing.com/quell-the-fire-of-inflammation-the-immense-power-of-proteolytic-enzyme-therapy/
14. ibid
15. Bromelain. Retrieved April 26, 2014 : http://www.webmd.com/vitamins-supplements/ingredientmono-1089-BROMELAIN.aspx?activeIngredientId=1089&activeIngredientName=BROMELAIN
16. The Microbes in Your Gut May be Making You Fat. Retrieved April 29, 2014: http://www.livescience.com/41954-gut-microbes-make-you-fat.html
17. ibid
18. Certain probiotics could help women lose weight, study finds. Retrieved April 30, 2014:
http://www.sciencedaily.com/releases/2014/01/140128103537.htm
19. Why Use Probiotics For Candida? Retrieved Apriil 30, 2014: http://www.thecandidadiet.com/probiotics.htm

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Disclaimer: Consult your physician before beginning any diet or exercise program. Dr. Miranda’s protocol is offered as generalized information and should not be construed as medical advice.
Copyright (c) 2014 Miranda Jorgenson. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of the author